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It is a strong agonist at the μ-opioid receptors. Fentanyl is estimated to be between 50 and 100 times as potent as morphine.
Fentanyl 100mcg patch was first made by Paul Janssen in 1960,following the medical inception of pethidine (also known as meperidine, marketed as Demerol) several years earlier.
Janssen developed fentanyl by assaying analogues of the structurally related drug pethidine for opioid activity.
The widespread use of fentanyl triggered the production of fentanyl citrate (the salt formed by combining fentanyl and citric acid in a 1:1 stoichiometry), which entered medical use as a general anaesthetic under the trade name Sublimaze in the 1960s.
Following this, many other fentanyl analogues were developed and introduced into medical practice, including sufentanil, alfentanil, remifentanil, and lofentanil.
Fentanyl 100mcg patch In the mid-1990s, fentanyl was introduced for palliative use with the fentanyl patch, followed in the next decade by the introduction of the fentanyl lollipop, dissolving tablets, and sublingual spray which are resorbed through the skin inside the mouth.As of 2012 fentanyl was the most widely used synthetic opioid in medicine.In 2013, 1700 kilograms were used globally.
Fentanyl is also used as a recreational drug, and this use has led to thousands of overdose deaths each year in recent years.
Deaths have also resulted from improper medical use.
Fentanyl has a relatively wide therapeutic index (270) which makes it a very safe surgical anesthetic when monitored carefully; however, its extreme potency requires careful measurements of highly diluted fentanyl in solution.
attempting to accurately measure a dose of pure fentanyl powder is impractical without advanced scientific equipment as an effective dose and a lethal dose of fentanyl powder placed next to each other would be difficult or impossible to differentiate with the naked eye
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